Tetracycline hydrochloride is a tetracycline antibiotic with the chemical formula C₂₂H₂₅ClN₂O₈, molecular weight 480.896, CAS number 64-75-5, yellow crystalline powder, soluble in water, methanol, ethanol, insoluble in ether and hydrocarbons.
CAS No. :
64-75-5EINECS :
200-593-8Package :
25KG/DRUMBrand :
TOPINCHEM®Origin :
CHINAFormula :
C22H25ClN2O8Minimum Order :
200KGItem :
Tetracycline hydrochlorideDescription
Tetracycline hydrochloride is a broad-spectrum antibiotic that has bactericidal effects at high concentrations. In addition to common Gram positive bacteria, Gram negative bacteria, and anaerobic bacteria, most species of rickettsia, mycoplasma, chlamydia, atypical mycobacteria, spirochetes, actinomycetes, anthrax bacteria, Listeria monocytogenes, Clostridium difficile, and Nocardia are sensitive to this product.
Specification
| TESTS | SPECIFICATIONS | RESULTS |
| DESCRIPTION | A The sample exhibits maxima only at the samewavelengths as that of a similar preparation ofthe standard in the infrared spectrum | Passes test |
| B The retention time of the major peak of thesample solution corresponds to that of thestandard solution, as obtained in the Assay. | Passes test | |
| C Meets the requirements ofthe tests forChloride. | Passes test | |
| SPECIFIC ROTATION | -240° to -255° | -252° |
| CRYSTALLINITY | Meets with specification | Passes test |
| pH | 1.8 to 2.8 | 2.5 |
| LOSS ON DRYING | Not more than 2.0% | 0.3% |
| RELATED SUBSTANCES(HPLC) | ||
| EPITETRACYCLINE | Not more than 3.0% | 1.53% |
| 4-EPIANHYDROTETRACYCLINE | Not more than 2.0% | Less than disregard limit |
| ANHYDROTETRACYCLINE | Not more than 0.5% | 0.12% |
| 2-ACETYLANALOG | Not more than 1.4% | 0.78% |
| ANY INDIVIDUAL UNSPECIFIED IMPURITY | Not more than 0.10% | 0.09% |
| SUM OF IMPURITIES | Not more than 4.0% | 2.58% |
| ASSAY OF TETRACYCLINE HYDROCHLORIDE(AS IS) | Not Less than 900ug/mg | 984ug/mg |
| RESIDUAL SOLVENTS | ||
| ACETONE | Not more than 500ppm | 4ppm |
| 1-BUTANOL | Not more than 5000ppm | 1953ppm |
Application
1. Tetracycline hydrochloride is an antibiotic, which is used to treat non bacterial infections such as chlamydia infection, rickettsiasis, mycoplasma pneumonia, and relapsing fever. It is also used to treat respiratory system, bile duct, urinary tract infections, and skin and soft tissue infections caused by brucellosis, cholera, tularemia, rat bite fever, anthrax, tetanus, pestis, actinomycosis, gas gangrene, and sensitive bacteria.
2. It belongs to broad-spectrum antibiotics.
3. It is a broad-spectrum antibacterial agent that has bactericidal effects at high concentrations.
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