Spironolactone is an artificially synthesized steroid compound with the chemical formula C24H32O4S, mainly used as a low efficiency diuretic. Its structure is similar to aldosterone and it is a competitive inhibitor of aldosterone.
CAS No. :
52-01-7EINECS :
200-133-6Package :
25kg/drumBrand :
TOPINCHEM®Origin :
CHINAFormula :
C24H32O4SMinimum Order :
200KGItem :
SpironolactoneDescription
Spironolactone is a white or off white crystalline powder with a slight bitter taste, odorless or slightly thiol odor. It is highly soluble in chloroform, insoluble in water, soluble in ethanol, and easily soluble in benzene or ethyl acetate.
Specification
| Test Items | Standard | Results |
| Appearance | Light cream-colored to light tan, crystalline powder | Light creamycrystalline powder |
| Identification | A: IRIdentification，The spectrum of the tested magentais the same as that of the reference | Conforms |
| B:HPLCIdentification，The retention time of the major peakof the Sample solution correspondsto that of the Standard solution, asobtained in the Assay | Conforms | |
| Specific Rotation | -41.0°to-45.0(C=10 in alcohol) | -43.7° |
| Loss on drying | NMT 0.5% | 0.18% |
| Mercapto Compounds | NMT 0.10 mL of 0.010 N iodine is consumed. | Conforms |
| Related substances(HPLC) | Impurity A NMT 0.2% | 0.05% |
| Impurity B NMT 0.2% | <0.05% | |
| Impurity C NMT 0.2% | Not detected | |
| Impurity D NMT 0.3% | <0.05% | |
| Spironolactone epimer NMT 0.3% | <0.05% | |
| Impurity I NMT 0.1% | Not detected | |
| Any unspecified impurity NMT 0.10% | 0.06% | |
| Total impurities NMT 1.0% | 0.19% | |
| Residual solvent | Methanol NMT3000ppm | 90ppm |
| Thioacetic acid NMT1000ppm | 46ppm | |
| Ethyl acetate NMT5000ppm | 49ppm | |
| Assay(HPLC) | 97.0%~103.0%,on the dried basis | 100.6% |
| Particle size | Volume below(25)um>90.0% | 100.00% |
| Conclusion | conform |
Application
1. Used as a diuretic.
2. Used for treating liver disease, low renin hypertension, and hypokalemia.
3. Active metabolites of lactones.
4. A low efficiency diuretic.
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