Ciprofloxacin Hydrochloride is a broad-spectrum antibiotic which means that it's used to treat a number of bacterial infections.
CAS No. :
93107-08-5EINECS :
642-985-5Package :
25KG/DRUMBrand :
TOPINCHEM®Origin :
CHINAFormula :
C17H18FN3O3.HClMinimum Order :
25KGItem :
Ciprofloxacin HydrochlorideDiscription
Ciprofloxacin Hydrochloride is the hydrochloride salt form of ciprofloxacin, a fluoroquinolone related to nalidixic acid with antibacterial activity. Ciprofloxacin hydrochloride exerts its bactericidal effect by interfering with the bacterial DNA gyrase, thereby inhibiting the DNA synthesis and preventing bacterial cell growth.
Specification
| (Tests) | (Acceptance Criteria) | (Results) | ||
| Faintly yellowish to light yellow crystalline powder. | Faintly yellowish crystalline powder | |||
| Appearance | ||||
| Characters | ||||
| Sparingly soluble in water;slightly soluble in acetic acid and in methanol;very slightly soluble in dehydrated alcohol;practically insoluble in acetone,in acetonitrile, in ethyl acetate,in hexane,and in methylene chloride. |
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| Solubility | ||||
| / | ||||
| (1)IR:Conforms to the spectrum of Ciprofloxacin Hydrochloride RS. | ||||
| (2)HPLC:The retention time of the major peak of the Sample solution corresponds to that of the Standard solution,as obtained in the Assay |
||||
| Identification | (3)Responds to the tests for chloride. | Conforms | ||
| PH | 3.0～4.5(25mg/ml solution in water | 3.9 | ||
| Water | 4.7～6.7% | 6.30% | ||
| Residue on ignition | ≤0.1% | 0.01% | ||
| Heavy metals | ≤20ppm | <20ppm | ||
| Sulphates | ≤400ppm | <400ppm | ||
| 1) | ≤0.2% | 0.07% | ||
| Ciprofloxacin ethylenediamine analog | ||||
| (HPLC) Organic impurities | ||||
| 2)Fluoroquinolonic acid | ≤0.2% | 0.02% | ||
| 3)Any other individual impurity | ≤0.2% | 0.06% | ||
| 4)The sum of all impurities | ≤0.5% | 0.13% | ||
| (HPLC)Assay | 98.0%～102.0%of C₁₇H₁₈FN₃O₃ ·HCL(Calculated on the anhydrous basis) | 100.10% | ||
| Residual solvents | (1)Ethanol | ≤5000ppm | 120ppm | |
| (2)Toluene | ≤890ppm | Not detected | ||
Application
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