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High Quality EP Grade Indomethacin Micronized CAS 53-86-1

High Quality EP Grade Indomethacin Micronized CAS 53-86-1

Indomethacin is a white or slightly yellow crystalline powder, which is a potent non corticosteroid anti-inflammatory, antipyretic, and analgesic drug.

  • CAS No. :

    53-86-1
  • EINECS :

    200-186-5
  • Package :

    25KG/DRUM
  • Brand :

    TOPINCHEM®
  • Origin :

    CHINA
  • Formula :

    C19H16ClNO4
  • Minimum Order :

    100KG
  • Item :

    Indomethacin

High Quality EP Grade Indomethacin Micronized CAS 53-86-1

 

Description

Indomethacin is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic, and analgesic effects. It exerts anti-inflammatory effects by inhibiting cyclooxygenase and reducing prostaglandin synthesis, while its antipyretic effect is related to the inhibition of prostaglandin synthesis in the hypothalamus.

 

Specification

Test items Specification Results
Description White or yellow crystalline powder No foul or almost no smell White crystalline powder
Solubility Practically insoluble in water, sparingly soluble in ethanol(96 percent) Complies
*Particle size As for customer information D90< 40μm
Identification    
Melting Point A: 158- 162 160- 161
Infrared absorption The IR of sample which to be examined Complies
corresponding to the reference indomethacin CRS
Tests    
Related substance Any unspecified impurities NMT 0.10% 0.04%
Total impurities  0.3% 0.08%
Loss on drying 0.5% 0.10%
Sulfated ash 0.1% 0.08%
Assay It should contain more than 98.0% and less than 102.0% of C19H16ClNO4 calculated on dry substance. 100.30%
Microbial limits Aerobic bacteria per 1g must not exceed the total number of 103  cfu . <10cfu
Fungi and yeast per 1g must not exceed 102  cfu <10cfu
Escherichia coli per 1g must not be detected Not detected

 

 

Application

Indomethacin is anti-inflammatory and has a significant antipyretic effect. It is mainly used for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, etc. that are not easily tolerated or have no significant therapeutic effects on salicylic acid drugs.

 

Indomethacin Micronized CAS 53-86-1

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