Indomethacin is a white or slightly yellow crystalline powder, which is a potent non corticosteroid anti-inflammatory, antipyretic, and analgesic drug.
CAS No. :
53-86-1EINECS :
200-186-5Package :
25KG/DRUMBrand :
TOPINCHEM®Origin :
CHINAFormula :
C19H16ClNO4Minimum Order :
100KGItem :
IndomethacinHigh Quality EP Grade Indomethacin Micronized CAS 53-86-1
Description
Indomethacin is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic, and analgesic effects. It exerts anti-inflammatory effects by inhibiting cyclooxygenase and reducing prostaglandin synthesis, while its antipyretic effect is related to the inhibition of prostaglandin synthesis in the hypothalamus.
Specification
| Test items | Specification | Results |
| Description | White or yellow crystalline powder No foul or almost no smell | White crystalline powder |
| Solubility | Practically insoluble in water, sparingly soluble in ethanol(96 percent) | Complies |
| *Particle size | As for customer information | D90< 40μm |
| Identification | ||
| Melting Point | A: 158℃- 162℃ | 160℃- 161℃ |
| Infrared absorption | The IR of sample which to be examined | Complies |
| corresponding to the reference indomethacin CRS | ||
| Tests | ||
| Related substance | Any unspecified impurities NMT 0.10% | 0.04% |
| Total impurities ≤0.3% | 0.08% | |
| Loss on drying | ≤0.5% | 0.10% |
| Sulfated ash | ≤0.1% | 0.08% |
| Assay | It should contain more than 98.0% and less than 102.0% of C19H16ClNO4 calculated on dry substance. | 100.30% |
| Microbial limits | Aerobic bacteria per 1g must not exceed the total number of 103 cfu . | <10cfu |
| Fungi and yeast per 1g must not exceed 102 cfu | <10cfu | |
| Escherichia coli per 1g must not be detected | Not detected |
Application
Indomethacin is anti-inflammatory and has a significant antipyretic effect. It is mainly used for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, etc. that are not easily tolerated or have no significant therapeutic effects on salicylic acid drugs.
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